Overexpression of innate immune response genes in a model of recessive polycystic kidney disease


Defects in the primary cilium/basal body complex of renal tubular cells cause polycystic kidney disease (PKD). To uncover pathways associated with disease progression, kidney transcriptome of 10-day-old severely and mildly affected cpk mice, a model of recessive PKD, were examined using Affymetrix GeneChips.


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Mrug M, Zhou J, Woo Y, Cui X, Szalai AJ, Novak J, Churchill GA, Guay-Woodford LM
Kidney Int. 2008 Jan;73(1):63-76 PMCID: PMC

Saltwater marsh in Acadia National Park