Overexpression of innate immune response genes in a model of recessive polycystic kidney disease

Description

Defects in the primary cilium/basal body complex of renal tubular cells cause polycystic kidney disease (PKD). To uncover pathways associated with disease progression, kidney transcriptome of 10-day-old severely and mildly affected cpk mice, a model of recessive PKD, were examined using Affymetrix GeneChips.

Data

• README file
• Design file

CEL files

• 1M Mouse430_2.CEL
• 1S Mouse430_2.CEL
• 2M Mouse430_2.CEL
• 2S Mouse430_2.CEL
• 3M Mouse430_2.CEL
• 3S Mouse430_2.CEL
• 4M Mouse430_2.CEL
• 4S Mouse430_2.CEL
• 5M Mouse430_2.CEL
• 5S Mouse430_2.CEL
• 6M Mouse430_2.CEL
• 6S Mouse430_2.CEL
• 7M Mouse430_2.CEL
• 7S Mouse430_2.CEL

Publications 

Mrug M, Zhou J, Woo Y, Cui X, Szalai AJ, Novak J, Churchill GA, Guay-Woodford LM
Kidney Int. 2008 Jan;73(1):63-76 PMCID: PMC